Research
Our main research aim is to develop novel chemical compounds capable to interact simultaneously with two or more biological targets. The Multi-Target Directed Ligand Strategy (MTDL) has grown in the last decades as a valid alternative to classical mono-targeting therapy. In particular, our focus is the design and synthesis of molecules able to find a place in cancer and neurodegenerative disorders' therapy.
Main currently research topics are:
::: Design and synthesis of new molecules targeting chemoresistance in cancer therapy
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::: Synthesis of new multitarget drugs through the combination of pharmacophoric moieties for the neurodegenerative diseases
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::: Synthesis of small molecules to treat GBM.
Relevant Fundings
For the complete list, check the Curriculum Vitae of Simona Rapposelli, here.
2024-2029 Public Funding
Associazione Italiana Ricerca sul cancro (IG-AIRC)
Potential therapeutic application of a novel class of thyromimetics in NAFLD-associated HCC –AIRC
Role of Participant
2023-2025 Public Funding
PRIN2022 PNRR
Glucose-6-phosphate dehydrogenase (G6PD) inhibitors for treatment of NAFLD-related hepatocellular carcinoma: synthesis and bio-pharmacological characterization.
Role of Principal Investigator
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2023-2024 Private Funding
FLORATEK PHARMA SA
​Design, synthesis and biological evaluation of bioactive small molecules for therapeutic purpose
Role of Principal Investigator​​​
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2022-2025 Public Funding
Preventive and Predictive Medicine
​THE - Tuscany Health Ecosystem "Ecosistema dell’innovazione sulle scienze e le tecnologie della vita in Toscana – Spoke 2
Role of Participant
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2021-2024 Public Funding
Telethon Grant Projects (PI: Marchese M)
Insight CLN5: Approaching therapies in the neuronal ceroid lipofuscinosis, using Zebrafish as a Tool
Role: Partecipant
2020-2023 Public Funding
Bando Ricerca Salute 2018 - Progetto LINEA 1 (Coordinator: Santorelli F)
Neurodegenerative disorders throughout the lifespan. Autophagy-dependent biomarkers for trial readiness from infantile neuronal ceroid -lipofuscinoses to senile dementias (DEM-AGING)
Role of Unit Principal Investigator
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2019-2021 Public Funding
PRIN2017 - Grant N° 2017XP72RF (National PI: Calderone V.)
Hydrogen Sulfide in the Vascular inflamm-Aging: role, therapeutic Opportunities and development of novel pharmacological tools for age-related cardiovascular diseases (SVAgO)
Role of Partecipant
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2019-2020 Public Funding
Research project focused on the synthesis of new multitarget compounds for the treatment of neurodegenerative diseases (LIPID-AD)
Funded by: University of Pisa
Role of Principal Investigator
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2015 - 2020 Private Funding
Research project focused on the synthesis of new multitarget compounds for the treatment of multifactorial pathologies
Funded by: International Society for Drug Development (ISDD) (Milan, Italy)
Role of Scientific Director
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2014 - 2015 Private Funding
Research project focused on design and synthesis of anticancer drugs
Funded by: International Society for Drug Development (ISDD) (Milan, Italy)
Role of Scientific Director
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2013 - 2015 Private Funding
Reseach project in the field of anticancer drugs and regenerative medicine
Funded by: International Society for Drug Development (ISDD) (Milan, Italy)
Role of Scientific Director
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2012 - 2015 Public Funding
Future in Research - Grant N° RBFR10ZJQT ( National PI: Marinelli L)
Mitochondrial medicinal chemistry against cell death-resistant cancers
Role of Unit Principal Investigator
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2011 - 2013 Public Funding
Research Projects of National Interest (PRIN) - Grant N° 20097FJHPZ_003 ( National PI: Perrone R)
Design and synthesis of new arylethylphenyl-derivatives as P-gp modulators for the treatment of neurodegenerative diseases and/or cerebral tumours
Role of Unit Principal Investigator
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2007 - 2008 Public Funding
Fondazione Cassa di risparmio Lucca (PI: Rapposelli S)
Development of new molecules for the treatment of myocardial ischemia
Role of Principal investigator